Dopaminergic drugs modulate learning rates and perseveration in Parkinson's patients in a dynamic foraging task.

@article{Rutledge2009DopaminergicDM,
  title={Dopaminergic drugs modulate learning rates and perseveration in Parkinson's patients in a dynamic foraging task.},
  author={Robb B. Rutledge and Stephanie C. Lazzaro and Brian Lau and Catherine Myers and Mark A. Gluck and Paul William Glimcher},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 48},
  pages={15104-14}
}
Making appropriate choices often requires the ability to learn the value of available options from experience. Parkinson's disease is characterized by a loss of dopamine neurons in the substantia nigra, neurons hypothesized to play a role in reinforcement learning. Although previous studies have shown that Parkinson's patients are impaired in tasks involving learning from feedback, they have not directly tested the widely held hypothesis that dopamine neuron activity specifically encodes the… CONTINUE READING
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