Dopaminergic drugs in type 2 diabetes and glucose homeostasis.

  title={Dopaminergic drugs in type 2 diabetes and glucose homeostasis.},
  author={Felicitas Lopez Vicchi and Guillermina Mar{\'i}a Luque and Bel{\'e}n Brie and Juan Patricio Nogueira and Isabel Garcia Tornadu and Damasia Bec{\'u}-Villalobos},
  journal={Pharmacological research},
The importance of dopamine in central nervous system function is well known, but its effects on glucose homeostasis and pancreatic β cell function are beginning to be unraveled. Mutant mice lacking dopamine type 2 receptors (D2R) are glucose intolerant and have abnormal insulin secretion. In humans, administration of neuroleptic drugs, which block dopamine receptors, may cause hyperinsulinemia, increased weight gain and glucose intolerance. Conversely, treatment with the dopamine precursor l… CONTINUE READING
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