Dopaminergic denervation of striatum results in elevated expression of NR2A subunit.

@article{Uas1996DopaminergicDO,
  title={Dopaminergic denervation of striatum results in elevated expression of NR2A subunit.},
  author={Jolanta Ułas and Carl Cotman},
  journal={Neuroreport},
  year={1996},
  volume={7 11},
  pages={1789-93}
}
An imbalance between glutamate and dopamine in the striatum may contribute to the pathophysiology of Parkinson's disease. We therefore studied the effect of dopaminergic denervation of the rat striatum (unilateral 6-OHDA lesions of the medial forebrain bundle) on NMDA receptors. The expression of NMDA receptor genes (NR1, NR2A-B) was examined by in situ hybridization using oligonucleotide probes, and binding to NMDA receptors assessed using L-[3H]glutamate. Three weeks after lesioning… CONTINUE READING