Dopaminergic control of synaptic plasticity in the dorsal striatum.

  title={Dopaminergic control of synaptic plasticity in the dorsal striatum.},
  author={Diego Centonze and Barbara Picconi and Paolo Gubellini and Giorgio Bernardi and Paolo Calabresi},
  journal={The European journal of neuroscience},
  volume={13 6},
Cortical glutamatergic and nigral dopaminergic afferents impinge on projection spiny neurons of the striatum, providing the most significant inputs to this structure. Isolated activation of glutamate or dopamine (DA) receptors produces short-term effects on striatal neurons, whereas the combined stimulation of both glutamate and DA receptors is able to induce long-lasting modifications of synaptic excitability. Repetitive stimulation of corticostriatal fibres causes a massive release of both… CONTINUE READING
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