Dopaminergic control of cognitive flexibility in humans and animals

  title={Dopaminergic control of cognitive flexibility in humans and animals},
  author={Marianne Klanker and M. Feenstra and Damiaan Denys},
  booktitle={Front. Neurosci.},
Striatal dopamine (DA) is thought to code for learned associations between cues and reinforcers and to mediate approach behavior toward a reward. Less is known about the contribution of DA to cognitive flexibility-the ability to adapt behavior in response to changes in the environment. Altered reward processing and impairments in cognitive flexibility are observed in psychiatric disorders such as obsessive compulsive disorder (OCD). Patients with this disorder show a disruption of functioning… CONTINUE READING
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