Dopaminergic-based pharmacotherapies for depression.

  title={Dopaminergic-based pharmacotherapies for depression.},
  author={George I. Papakostas},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  volume={16 6},
The serendipitous discovery of the precursors of two of the major contemporary antidepressant families during the late 1950s, iproniazid for the monoamine oxidase inhibitors (MAOIs) and imipramine for the tricyclic antidepressants (TCAs), has guided the subsequent development of antidepressant compounds with predominantly serotonergic, noradrenergic or combined serotonergic and noradrenergic activity. Unfortunately, however, many depressed patients continue to remain symptomatic despite… CONTINUE READING
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