Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D2-induced formation of anandamide

@article{Solinas2010DopaminergicAO,
  title={Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D2-induced formation of anandamide},
  author={Marcello Solinas and Gianluigi Tanda and Carrie E. Wertheim and Steven R. Goldberg},
  journal={Psychopharmacology},
  year={2010},
  volume={209},
  pages={191-202}
}
Although delta-9-tetreahydrocannabinol (THC)-induced elevations in accumbal dopamine levels are believed to play an important role in the abuse-related effects of cannabis, little direct evidence has been provided that the dopaminergic system is involved in the psychotropic effects of THC. The objective of this study is to investigate whether drugs activating or blocking the dopaminergic system modulate the discriminative effects of THC. In rats that had learned to discriminate 3 mg/kg of THC… CONTINUE READING

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