Dopaminergic antagonism within the nucleus accumbens or the amygdala produces differential effects on intravenous cocaine self-administration under fixed and progressive ratio schedules of reinforcement.

@article{McGregor1993DopaminergicAW,
  title={Dopaminergic antagonism within the nucleus accumbens or the amygdala produces differential effects on intravenous cocaine self-administration under fixed and progressive ratio schedules of reinforcement.},
  author={Ailsa McGregor and David C. S. Roberts},
  journal={Brain research},
  year={1993},
  volume={624 1-2},
  pages={245-52}
}
Bilateral intracerebral injections of the D1 receptor antagonist, SCH 23390, were administered into the nucleus accumbens (NACC) or amygdala (AMY) immediately prior to an i.v. cocaine self-administration session. Injection into both sites produced a dose-dependent (0.1-2.0 micrograms/injection) increase in the rate of cocaine self-administration under a fixed ratio (FR) schedule of reinforcement (1.5 mg/kg/injection). However, injection into the AMY produced a significantly greater increase in… CONTINUE READING