Dopaminergic and serotonergic mediation of the discriminable effects of ergot alkaloids.

@article{Holohean1982DopaminergicAS,
  title={Dopaminergic and serotonergic mediation of the discriminable effects of ergot alkaloids.},
  author={A. Holohean and F. White and J. Appel},
  journal={European journal of pharmacology},
  year={1982},
  volume={81 4},
  pages={
          595-602
        }
}
  • A. Holohean, F. White, J. Appel
  • Published 1982
  • Chemistry, Medicine
  • European journal of pharmacology
  • The involvement of dopamine (DA) and serotonin (5-HT) neuronal systems in the discriminative stimulus effects of various ergot derivatives was assessed by administering four ergots to 36 rats which had been trained to discriminate either apomorphine (APO) or d-lysergic acid diethylamide (LSD) from saline. Lergotrile, lisuride and LSD substituted for APO (0.25 mg/kg) while bromocriptine and ergonovine (ergometrine) did not; only lisuride mimicked LSD (0.08 mg/kg). Antagonism tests showed that… CONTINUE READING
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