Dopaminergic and serotonergic autoreceptor stimulation effects are equivalent and additive in the suppression of spontaneous and cocaine induced locomotor activity.

@article{Carey2004DopaminergicAS,
  title={Dopaminergic and serotonergic autoreceptor stimulation effects are equivalent and additive in the suppression of spontaneous and cocaine induced locomotor activity.},
  author={Robert J. Carey and Gail DePalma and Ernest N Damianopoulos and Anthony Hopkins and Arielle B Shanahan and Christian P M{\"u}ller and Joseph P. Huston},
  journal={Brain research},
  year={2004},
  volume={1019 1-2},
  pages={134-43}
}
We used the D(2) receptor agonist, apomorphine (APO) and the 5-HT(1A) receptor agonist, 8-OHDPAT (8OH) in a low dose range to stimulate autoreceptors and in this way assess the separate and combined effects of reduced DA and 5-HT activity upon spontaneous and cocaine induced locomotor behavior. Two separate experiments were conducted. In the first experiment, separate groups of rats (N=10) were tested with either saline, 8OH, APO or 8OH plus APO (0.01, 0.025, 0.05 mg/kg). At 0.05 mg/kg, 8OH and… CONTINUE READING
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