Dopaminergic and cholinergic involvement in the discriminative stimulus effects of nicotine and cocaine in rats

@article{Desai2003DopaminergicAC,
  title={Dopaminergic and cholinergic involvement in the discriminative stimulus effects of nicotine and cocaine in rats},
  author={Rajeev I. Desai and David J. Barber and Philip Terry},
  journal={Psychopharmacology},
  year={2003},
  volume={167},
  pages={335-343}
}
RationalePrevious work has demonstrated asymmetrical cross-generalization between the discriminative stimulus effects of nicotine and cocaine: nicotine fully substitutes for cocaine, whereas cocaine only partially substitutes for nicotine. The factors responsible for the similarities and differences between the two drugs remain unclear.ObjectiveThe study tested the involvement of dopaminergic and/or cholinergic mechanisms in the discriminative stimulus effects of nicotine and cocaine.MethodsOne… 
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TLDR
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Behavioral and neuropharmacological characterization of nicotine as a conditional stimulus.
TLDR
In rats, the pharmacological (interoceptive) effects of 0.4 mg/kg nicotine can serve as a conditional stimulus in a Pavlovian conditioning task and a role for N-methyl-D-aspartate receptors in expression of nicotine-evoked conditioned responding is identified.
Topiramate does not alter nicotine or cocaine discrimination in rats
The effects of topiramate, a potential treatment for drug dependence, were evaluated in two groups of rats trained to discriminate the administration of either 0.4 mg/kg nicotine or 10 mg/kg cocaine
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