Dopaminergic activity and the discriminative stimulus effects of mu opioids in pigeons: importance of training dose and attenuation by the D3 agonist (±)-7-OH-DPAT

@article{Cook1998DopaminergicAA,
  title={Dopaminergic activity and the discriminative stimulus effects of mu opioids in pigeons: importance of training dose and attenuation by the D3 agonist (±)-7-OH-DPAT},
  author={Charles D. Cook and Mitchell J. Picker},
  journal={Psychopharmacology},
  year={1998},
  volume={136},
  pages={59-69}
}
 The present investigation examined the effects of several dopaminergic compounds in pigeons trained to discriminate either a 0.1 (low) or 5.6 (high) mg/kg dose of the mu opioid butorphanol from saline. Various dopamine (DA) re-uptake inhibitors, releasers, a D1 agonist, a D2 agonist and a D3 agonist engendered partial substitution (50–79% butorphanol responding) for the butorphanol stimulus in the low-dose group. In the high-dose group, with a few exceptions, these compounds produced… CONTINUE READING
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Antagonism of the antinociceptive and discriminative stimulus effects of mu opioids by the dopamine D 3 agonist ( ± ) - 7 - hydroxy - dipropylaminotetralin [ ( ± ) - 7 - OH - DPAT ]

  • CD Cook, MJ Picker
  • Soc Neurosci Abstr
  • 1997

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