Dopaminergic Modulation of Effort-Related Choice Behavior as Assessed by a Progressive Ratio Chow Feeding Choice Task: Pharmacological Studies and the Role of Individual Differences

@article{Randall2012DopaminergicMO,
  title={Dopaminergic Modulation of Effort-Related Choice Behavior as Assessed by a Progressive Ratio Chow Feeding Choice Task: Pharmacological Studies and the Role of Individual Differences},
  author={P. Randall and M. Pardo and E. Nunes and Laura L{\'o}pez Cruz and V. K. Vemuri and A. Makriyannis and Y. Baqi and C. M{\"u}ller and M. Correa and J. Salamone},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
  • P. Randall, M. Pardo, +7 authors J. Salamone
  • Published 2012
  • Biology, Medicine
  • PLoS ONE
  • Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response requirements, and instead select less effortful food-seeking behaviors. In the present study, the effects of several drug treatments were assessed using a progressive ratio (PROG)/chow feeding concurrent choice task. With this task, rats can lever press on a PROG schedule… CONTINUE READING
    The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences
    • 66

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