Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR

@article{Schicknick2008DopaminergicMO,
  title={Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR},
  author={Horst Schicknick and Bj{\"o}rn H. Schott and Eike Budinger and K. H. Smalla and Anett Riedel and Constanze I. Seidenbecher and Henning Scheich and Eckart D. Gundelfinger and Wolfgang Tischmeyer},
  journal={Cerebral Cortex (New York, NY)},
  year={2008},
  volume={18},
  pages={2646 - 2658}
}
Previous studies in the auditory cortex of Mongolian gerbils on discrimination learning of the direction of frequency-modulated tones (FMs) revealed that long-term memory formation involves activation of the dopaminergic system, activity of the protein kinase mammalian target of rapamycin (mTOR), and protein synthesis. This led to the hypothesis that the dopaminergic system might modulate memory formation via regulation of mTOR, which is implicated in translational control. Here, we report that… CONTINUE READING

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