Dopaminergic D1 and D2 receptor antagonists decrease prosomatostatin mRNA expression in rat striatum.

@article{Augood1991DopaminergicDA,
  title={Dopaminergic D1 and D2 receptor antagonists decrease prosomatostatin mRNA expression in rat striatum.},
  author={Sarah J. Augood and Hiroshi Kiyama and Richard Lewis Maxwell Faull and Piers C. Emson},
  journal={Neuroscience},
  year={1991},
  volume={44 1},
  pages={35-44}
}
The effect of acute dopamine receptor antagonist treatment on cellular prosomatostatin mRNA expression was investigated in the adult rat striatum using the technique of non-radioactive in situ hybridization. Adult female Wistar rats were given a single intraperitoneal injection of either raclopride (D2 antagonist), SCH 23390 (D1 antagonist) or the D1 (S) enantiomer SCH 23388. Animals were killed either 1, 3 or 9 h following the single i.p. injection and their brains rapidly removed. Striatal… CONTINUE READING

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