Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo.

  title={Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo.},
  author={D. F. Wong and James Harris and Shan Naidu and Fuji Yokoi and Stefano Marenco and Robert F. Dannals and Hayden T. Ravert and Myron Yaster and Anthony C Evans and Olivier Rousset and R. Nick Bryan and Albert Gjedde and Michael Kuhar and George R. Breese},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 11},
Dopamine (DA) deficiency has been implicated in Lesch-Nyhan disease (LND), a genetic disorder that is characterized by hyperuricemia, choreoathetosis, dystonia, and compulsive self-injury. To establish that DA deficiency is present in LND, the ligand WIN-35,428, which binds to DA transporters, was used to estimate the density of DA-containing neurons in the caudate and putamen of six patients with classic LND. Comparisons were made with 10 control subjects and 3 patients with Rett syndrome… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 52 extracted citations

Similar Papers

Loading similar papers…