Dopamine transporter relation to levodopa-derived synaptic dopamine in a rat model of Parkinson's: an in vivo imaging study.

@article{Sossi2009DopamineTR,
  title={Dopamine transporter relation to levodopa-derived synaptic dopamine in a rat model of Parkinson's: an in vivo imaging study.},
  author={Vesna Sossi and Katherine Dinelle and Geoffrey Topping and James E. Holden and Doris Doudet and Michael Schulzer and Thomas J. Ruth and A. Jon Stoessl and Ra{\'u}l de la Fuente-Fern{\'a}ndez},
  journal={Journal of neurochemistry},
  year={2009},
  volume={109 1},
  pages={85-92}
}
Studies showed that the dopamine (DA) transporter (DAT) modulates changes in levodopa-derived synaptic dopamine levels (Delta(DA)) in Parkinson's disease (PD). Here we evaluate the relationship between DAT and Delta(DA) in the 6-hydroxydopamine model of Parkinson's disease to investigate these mechanisms as a function of dopaminergic denervation and in relation to other denervation-induced regulatory changes. 27 rats with a unilateral 6-hydroxydopamine lesion (denervation approximately 20-97… CONTINUE READING

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