Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate.

  title={Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate.},
  author={N. Volkow and G. Wang and J. Fowler and S. Gatley and J. Logan and Y. Ding and R. Hitzemann and N. Pappas},
  journal={The American journal of psychiatry},
  volume={155 10},
  • N. Volkow, G. Wang, +5 authors N. Pappas
  • Published 1998
  • Medicine
  • The American journal of psychiatry
  • OBJECTIVE The therapeutic effects of methylphenidate in the treatment of attention deficit disorder have been attributed to its ability to increase the synaptic concentration of dopamine by blocking the dopamine transporters. However, the levels of dopamine transporter blockade achieved by therapeutic doses of methylphenidate are not known. This study measured, for the first time, dopamine transporter occupancy by orally administered methylphenidate in the human brain and its rate of uptake in… CONTINUE READING
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