Dopamine transporter imaging deficit predicts early transition to synucleinopathy in idiopathic rapid eye movement sleep behavior disorder.

@article{Iranzo2017DopamineTI,
  title={Dopamine transporter imaging deficit predicts early transition to synucleinopathy in idiopathic rapid eye movement sleep behavior disorder.},
  author={Alex Iranzo and Joan Santamar{\'i}a and Francesc Valldeoriola and M{\'o}nica Serradell and Manel Salamero and Carles Gaig and Aida Ni{\~n}erola-Baiz{\'a}n and Raquel S{\'a}nchez-Valle and Albert Llad{\'o} and Roberto de Marzi and Ambra Stefani and Klaus Seppi and Javier Pav{\'i}a and Birgit H{\"o}gl and Werner Poewe and Eduardo Tolosa and Francisco Lome{\~n}a},
  journal={Annals of neurology},
  year={2017},
  volume={82 3},
  pages={419-428}
}
OBJECTIVE To determine the usefulness of dopamine transporter (DAT) imaging to identify idiopathic rapid eye movement sleep behavior disorder (IRBD) patients at risk for short-term development of clinically defined synucleinopathy. METHODS Eighty-seven patients with polysomnography-confirmed IRBD underwent 123 I-FP-CIT DAT-SPECT. Results were compared to 20 matched controls without RBD who underwent DAT-SPECT. In patients, FP-CIT uptake was considered abnormal when values were two standard… CONTINUE READING