Dopamine transporter SLC6A3 genotype affects cortico-striatal activity of set-shifts in Parkinson's disease.

@article{Habak2014DopamineTS,
  title={Dopamine transporter SLC6A3 genotype affects cortico-striatal activity of set-shifts in Parkinson's disease.},
  author={Claudine Habak and Anne Noreau and Atsuko Nagano-Saito and B{\'e}atriz Mejia-Constain and Clotilde Degroot and Antonio P. Strafella and Sylvain Chouinard and Anne-Louise Lafontaine and Guy Rouleau and Oury Monchi},
  journal={Brain : a journal of neurology},
  year={2014},
  volume={137 Pt 11},
  pages={3025-35}
}
Parkinson's disease is a neurodegenerative condition that affects motor function along with a wide range of cognitive domains, including executive function. The hallmark of the pathology is its significant loss of nigrostriatal dopamine, which is necessary for the cortico-striatal interactions that underlie executive control. Striatal dopamine reuptake is mediated by the SLC6A3 gene (formerly named DAT1) and its polymorphisms, which have been largely overlooked in Parkinson's disease. Thirty… CONTINUE READING
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