Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity

@article{Kalivas1991DopamineTI,
  title={Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity},
  author={P. Kalivas and J. Stewart},
  journal={Brain Research Reviews},
  year={1991},
  volume={16},
  pages={223-244}
}
Progress has been made over the last 10 years in determining the neural mechanisms of sensitization induced by amphetamine-like psychostimulants, opioids and stressors. Changes in dopamine transmission in axon terminal fields such as the nucleus accumbens appear to underlie the expression of sensitization, but the actions of drugs and stressors in the somatodendritic regions of the A10/A9 dopamine neurons seem critical for the initiation of sensitization. Manipulations that increase… Expand
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