Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity

@article{Kalivas1991DopamineTI,
  title={Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity},
  author={Peter W. Kalivas and Jane Stewart},
  journal={Brain Research Reviews},
  year={1991},
  volume={16},
  pages={223-244}
}
Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies
TLDR
The distinctions between drugs in the induction and expression of sensitization indicate that behavioral sensitization can arise from multiple neuroadaptations in multiple brain nuclei, not only the result of distinct molecular targets for the drugs, but may also include a differential involvement of learned associations.
Role of Glutamate and Nitric Oxide in the Acquisition and Expression of Cocaine-Induced Conditioned Increases in Locomotor Activity
TLDR
The principal findings do indeed support a role for the mesoaccumbens dopamine projections in the development and expression of behavioral sensitization to psychomotor stimulants.
Gene expression profiling of morphine-induced neuronal adaptations
TLDR
Molecular changes in the nucleus accumbens after morphine exposure are investigated by measuring gene expression of a large number of genes during development of sensitization to morphine to indicate the type and timing of molecular and cellular responses.
ROLE OF DOPAMINE OF NUCLEUS ACCUMBENS IN BEHAVIORAL SENSITIZATION TO METHYLPHENIDATE
TLDR
The role of dopaminergic afferents of the NAc in the behavioral sensitization elicited by chronic treatment with methylphenidate, a psychostimulant that is widely used to treat attention deficit hyperactivity disorder, is investigated and two distinct responses were seen to the acute injection of MPD.
The role of dopamine D4 receptor in the induction of behavioral sensitization to amphetamine and accompanying biochemical and molecular adaptations.
TLDR
D dopamine D4 receptors play an important role in the induction of behavioral sensitization to Amp and accompanying adaptations in pre- and postsynaptic neural systems associated with the mesolimbocortical dopamine projections, and concurrent administration of PNU-101387G with Amp during pretreatment blocked the augmentation in Amp-induced dopamine release.
Modulation of Long-Term Depression by Dopamine in the Mesolimbic System
TLDR
It is found that both sets of synapses express LTD but that their basic triggering mechanisms differ, and that DA blocks the induction of LTD in the midbrain via activation of D2-like receptors but has minimal effects on LTD inThe NAc.
The dopamine D3 receptor and drug addiction
TLDR
BP 897 has the unprecedented property to reduce cocaine-seeking behavior induced by presentation of a cocaine-associated cue, without having any intrinsic reinforcing effect, and may represent new medications for drug addiction, with minimal liability to maintaining dependence.
Cellular Mechanisms of Behavioral Sensitization to Drugs of Abuse a
TLDR
These findings complement many studies showing that the amphetamine or depolarization-induced release of dopamine from striatal tissue slices or synaptosomes is enhanced in rats pretreated with repeated amphetamine and support an hypothesis that behavioral sensitization to amphetamine-like psychostimulants and opioids results from an action of these drugs in the ventromedial mesencephalon.
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