Dopamine synthesis capacity in patients with treatment-resistant schizophrenia.

  title={Dopamine synthesis capacity in patients with treatment-resistant schizophrenia.},
  author={Arsime Demjaha and Robin MacGregor Murray and Philip K. McGuire and Shitij Kapur and Oliver D. Howes},
  journal={The American journal of psychiatry},
  volume={169 11},
OBJECTIVE Elevated presynaptic striatal dopaminergic function is a robust feature of schizophrenia. However, the relationship between this dopamine abnormality and the response to dopamine-blocking antipsychotic treatments is unclear. The authors tested the hypothesis that in patients with schizophrenia the response to antipsychotic treatment would be related to the severity of presynaptic dopamine dysfunction, as indexed using [(18)F]-DOPA uptake positron emission tomography (PET). METHOD… CONTINUE READING
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