Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice

@article{Jin2012DopamineRV,
  title={Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice},
  author={Duo Jin and Shin-Ichi Muramatsu and Nobuaki Shimizu and Shigeru Yokoyama and Hirokazu Hirai and Kiyofumi Yamada and H. Liu and Haruhiro Higashida and Minako Hashii and Masahide Asano and Seitaro Ohkuma},
  journal={Neurochemistry International},
  year={2012},
  volume={61},
  pages={907-912}
}
A 16-kDa proteolipid, mediatophore, in Torpedo electric organs mediates Ca(2+)-dependent acetylcholine release. Mediatophore is identical to the pore-forming stalk c-subunit of the V0 sector of vacuolar proton ATPase (ATP6V0C). The function of ATP6V0C in the mammalian central nervous system is not clear. Here, we report transfection of adeno-associated viral vectors harboring rat ATP6V0C into the mouse substantia nigra, in which high potassium stimulation increased overflow of endogenous… CONTINUE READING
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