Dopamine regulates the electrical activity of frog melanotrophs through a G protein-mediated mechanism

@article{Valentun1991DopamineRT,
  title={Dopamine regulates the electrical activity of frog melanotrophs through a G protein-mediated mechanism},
  author={J. A. Valentun and Estelle Louiset and Hubert Vaudry and Lionel Cazin},
  journal={Neuroscience},
  year={1991},
  volume={44},
  pages={85-95}
}
Recently we have demonstrated that dopamine inhibits action potentials in cultured frog melanotrophs through D2 receptor-mediated activation of hyperpolarizing potassium current and reduction of calcium and sodium currents. Herein, the respective roles of G proteins, guanosine-5'-triphosphate and adenosine-3':5'-cyclic-monophosphate in dopamine-induced electrical responses were investigated using the whole-cell patch-clamp technique. Pretreatment of melanotrophs with pertussis toxin (1… CONTINUE READING
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