Dopamine receptors and transporters in Parkinson's disease and schizophrenia.

  title={Dopamine receptors and transporters in Parkinson's disease and schizophrenia.},
  author={Philip Seeman and Hyman B. Niznik},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={4 10},
The loss of midbrain dopamine in Parkinson's disease is accompanied by a matching loss in the dopamine transporter and a rise in the D1 and D2 receptor densities. This is found in the brain putamen and caudate tissues from unmedicated patients, and may account for the good early clinical response to L-dopa. Long-term L-dopa treatment reverts the receptor densities toward normal levels. Positron emission tomography (PET) data and in vitro data generally concur. In schizophrenia the density of… CONTINUE READING