Dopamine receptors and the dopamine hypothesis of schizophrenia.

@article{Seeman1987DopamineRA,
  title={Dopamine receptors and the dopamine hypothesis of schizophrenia.},
  author={Philip Seeman},
  journal={Synapse},
  year={1987},
  volume={1 2},
  pages={133-52}
}
The discovery of neuroleptic drugs in 1952 provided a new strategy for seeking a biological basis of schizophrenia. This entailed a search for a primary site of neuroleptic action. The Parkinsonian effects caused by neuroleptics suggested that dopamine transmission may be disrupted by these drugs. In 1963 it was proposed that neuroleptics blocked "monoamine receptors" or impeded the release of monoamine metabolites. The neuroleptic concentration in plasma water or cerebrospinal fluid was of the… CONTINUE READING
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