Dopamine receptors and learned helplessness in the rat: An autoradiographic study

@article{Kram2002DopamineRA,
  title={Dopamine receptors and learned helplessness in the rat: An autoradiographic study},
  author={Martin L Kram and Gerald L. Kramer and Patrick J. Ronan and Mark Steciuk and Frederick Petty},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2002},
  volume={26},
  pages={639-645}
}
(1) Disturbances of mesolimbic and mesocortical dopamine (DA) function have been implicated in the pathophysiology of several psychiatric disorders, including major depressive disorder. (2) Utilizing the learned helplessness (LH) animal model of clinical depression and quantitative autoradiography, the authors studied the densities of D1 and dopamine-2-like receptors (D2-like receptors) in medial prefrontal cortex, septum, nucleus accumbens and caudate nucleus in rats that received inescapable… CONTINUE READING

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