Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants.

@article{Drago1998DopamineRA,
  title={Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants.},
  author={John L Drago and P Padungchaichot and Domenico Accili and Sara Fuchs},
  journal={Developmental neuroscience},
  year={1998},
  volume={20 2-3},
  pages={188-203}
}
Recent advances in molecular biology have resulted in a number of genetically manipulated mice with defined changes at dopamine receptor and the dopamine transporter (DAT) loci. Mice with targeted mutations at the D1 receptor (D1R) are growth-retarded and show downregulated expression of dynorphin and substance P. Behavioral assessment indicates that mutants have deficiencies in spatial learning and initiating movement, as well as in responding to novel stimuli. D1R mutants do not become… CONTINUE READING

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