Dopamine receptors: from structure to function.

  title={Dopamine receptors: from structure to function.},
  author={C. Missale and S. R. Nash and S. W. Robinson and M. Jaber and M. Caron},
  journal={Physiological reviews},
  volume={78 1},
  • C. Missale, S. R. Nash, +2 authors M. Caron
  • Published 1998
  • Medicine, Biology
  • Physiological reviews
  • The diverse physiological actions of dopamine are mediated by at least five distinct G protein-coupled receptor subtypes. Two D1-like receptor subtypes (D1 and D5) couple to the G protein Gs and activate adenylyl cyclase. The other receptor subtypes belong to the D2-like subfamily (D2, D3, and D4) and are prototypic of G protein-coupled receptors that inhibit adenylyl cyclase and activate K+ channels. The genes for the D1 and D5 receptors are intronless, but pseudogenes of the D5 exist. The D2… CONTINUE READING
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