Dopamine receptor antagonists prevent expression, but not development, of morphine sensitization.

@article{Jeziorski1995DopamineRA,
  title={Dopamine receptor antagonists prevent expression, but not development, of morphine sensitization.},
  author={M Jeziorski and Francis J. White},
  journal={European journal of pharmacology},
  year={1995},
  volume={275 3},
  pages={235-44}
}
The present experiments determined the effects of selective dopamine receptor antagonists on the initiation and expression of sensitization to the locomotor-stimulating effects of morphine in rats. Although both the dopamine D1 receptor antagonist R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaz epine hydrochloride (SCH 23390, 0.25 mg/kg) and the dopamine D2 receptor antagonist eticlopride (0.1 mg/kg) suppressed the ability of morphine (10 mg/kg) to elicit sensitized… CONTINUE READING
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