Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice.

@article{Sahin1990DopamineRA,
  title={Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice.},
  author={I Sahin and Meral Tuncer and Mustafa Ilhan},
  journal={Archives internationales de physiologie et de biochimie},
  year={1990},
  volume={98 1},
  pages={
          7-9
        }
}
Central antimuscarinic actions of dopamine receptor agonists: N,N-dipropylaminotetrain (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127), were evaluated against oxotremorine-induced tremors in mice. Both TL-68 and RDS-127 inhibited the tremor intensity but were less potent than atropine. 
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S-Aroylmethyl N, N-Disubstituted Dithiocarbamates With Antiparkinson Activity
TLDR
The results suggest that some of these derivatives of S-aroylmethyl N,N- disubstituted dithiocarbamate derivatives have central antimuscarinic effects and antiparkinson activities.
Formulation and in vitro-in vivo evaluation of piribedil solid lipid micro- and nanoparticles.
TLDR
After an in vitro-in vivo evaluation of piribedil solid lipid particles developed for Parkinson's disease therapy, it has been determined that release rate could be controlled and piribingil bioavailability could be improved.
Formulation and in vitro-in vivo evaluation of piribedil solid lipid micro- and nanoparticles
TLDR
After an in vitro-in vivo evaluation of piribedil solid lipid particles developed for Parkinson's disease therapy, it has been determined that release rate could be controlled and piribingil bioavailability could be improved.

References

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TLDR
N-Alkylated derivatives of 2-amino-4,7-dimethoxyindan were prepared for evaluation of central and peripheral dopaminergic activity using biochemical and behavioral tests in the rat and cardiovascular responses in the cat and produced weak, transient effects in heart rate and blood pressure.
Dopaminergic effects of non-hydroxylated rigid analogs of apomorphine.
Anticholinergic activity of the dopamine receptor agonist, TL‐68 (N,N‐dipropyl‐2‐aminotetralin)
  • I. Sahin, M. Ilhan
  • Biology, Medicine
    The Journal of pharmacy and pharmacology
  • 1987
The anticholinergic properties of a dopamine receptor agonist, a non‐hydroxylated derivative of N,N‐dipropylaminotetralin (TL‐68), were evaluated using the guinea‐pig isolated tracheal strip and rat…
Effects of a novel dopamine-receptor agonist RDS-127 (2-N,N-di-n-propylamino-4,7-dimethoxyindane), on hormone levels and sexual behavior in the male rat
A new probe for heterogeneity in muscarinic receptors: 2-methyl-spiro-(1, 3-dioxolane-4, 3')-quinuclidine.
A striatal serotonergic involvement in the behavioural effects of anticholinesterase organophosphates.
An alternative approach to developing dopamine‐receptor agonists with central presynaptic actions following oral administration: A comparison between apomorphine, bromocriptine, and the novel compound RDS‐127 (2‐di‐n‐propylamino‐4,7‐dimethoxyindane)
TLDR
The inhibitory effects of RDS‐127 on locomotor activity were blocked by prior administration of sulpiride, suggesting the effects are mediated by DA receptors.
The central and peripheral activities of anti‐acetylcholine drugs. Some concepts of practical relevance
TLDR
The potencies of optically pure enantiomers of anti‐acetylcholine drugs which contain an asymmetric centre have been determined and appears to depend on the affinity constant rather than on the partition properties of the drug.