Dopamine receptor D1 and postsynaptic density gene variants associate with opiate abuse and striatal expression levels

Abstract

Opioid drugs are highly addictive and their abuse has a strong genetic load. Dopamine–glutamate interactions are hypothesized to be important for regulating neural systems central for addiction vulnerability. Balanced dopamine–glutamate interaction is mediated through several functional associations, including a physical link between discs, large homolog 4… (More)
DOI: 10.1038/mp.2012.140

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