Dopamine receptor 4 (DRD4) 7-repeat allele predicts methylphenidate dose response in children with attention deficit hyperactivity disorder: a pharmacogenetic study.

@article{Hamarman2004DopamineR4,
  title={Dopamine receptor 4 (DRD4) 7-repeat allele predicts methylphenidate dose response in children with attention deficit hyperactivity disorder: a pharmacogenetic study.},
  author={Stephanie Hamarman and John A. Fossella and Celal Ulger and Michael B Brimacombe and James Dermody},
  journal={Journal of child and adolescent psychopharmacology},
  year={2004},
  volume={14 4},
  pages={564-74}
}
OBJECTIVE Genetic polymorphisms of the dopamine neurotransmitter system have been identified in attention deficit hyperactivity disorder (ADHD). Since stimulant medications act through this system, we sought to determine if the 48 base pair VNTR polymorphism (7- repeat allele) of dopamine receptor gene DRD4 predicts methylphenidate responsiveness. METHODS Forty-five children, aged 7-15 years, with ADHD, confirmed by NIMH-DISC-IV, participated in this prospective pharmacogenetic study… CONTINUE READING

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