Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity.

@article{Trimmer1996DopamineNF,
  title={Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity.},
  author={Patricia A Trimmer and Tamara S Smith and Armelle B. J. Jung and James P. Bennett},
  journal={Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration},
  year={1996},
  volume={5 3},
  pages={233-9}
}
We have examined MPTP toxicity to dopamine neurons of mice homozygous for a transgenic knockout of the p53 growth control gene (p53-/-). MPTP at a total dose of 96 mg/kg administered in four doses over two days produced a non-homogeneous loss of striatal dopamine transport sites and quantitatively reduced 3H-mazindol binding to similar degrees in p53-/- and wild type controls 2 and 3 weeks after starting MPTP. Nigral DA neurons stained immunohistochemically for tyrosine hydroxylase were counted… CONTINUE READING

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