Dopamine modulates release from corticostriatal terminals.

  title={Dopamine modulates release from corticostriatal terminals.},
  author={Nigel S. Bamford and Siobhan Robinson and Richard D Palmiter and John A. Joyce and Cynthia A. Moore and Charles K. Meshul},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={24 43},
Normal striatal function is dependent on the availability of synaptic dopamine to modulate neurotransmission. Within the striatum, excitatory inputs from cortical glutamatergic neurons and modulatory inputs from midbrain dopamine neurons converge onto dendritic spines of medium spiny neurons. In addition to dopamine receptors on medium spiny neurons, D2 receptors are also present on corticostriatal terminals, where they act to dampen striatal excitation. To determine the effect of dopamine… CONTINUE READING
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