Dopamine metabolism increases in post-mortem schizophrenic basal ganglia

  title={Dopamine metabolism increases in post-mortem schizophrenic basal ganglia},
  author={Michio Toru and Toru Nishikawa and Nobuko Mataga and Mizuo Takashima},
  journal={Journal of Neural Transmission},
The dopamine-rich regions of post-mortem brains from 6 schizophrenics and 7 controls were analyzed. There were no significant changes in dopamine concentrations in basal ganglia and nucleus accumbens of schizophrenics compared with controls. Schizophrenic basal ganglia (putamen and caudate) showed significantly higher levels of homovanillic acid, and tyrosine hydroxylase activity. Among the schizophrenic patients, markedly high activity of tyrosine hydroxylase was measured in a patient… CONTINUE READING


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