Dopamine mediates striatal malonate toxicity via dopamine transporter-dependent generation of reactive oxygen species and D2 but not D1 receptor activation.

@article{Xia2001DopamineMS,
  title={Dopamine mediates striatal malonate toxicity via dopamine transporter-dependent generation of reactive oxygen species and D2 but not D1 receptor activation.},
  author={Xu Gang Xia and Nicole Schmidt and Peter Teismann and Boris Ferger and J{\"o}rg Bernhard Schulz},
  journal={Journal of neurochemistry},
  year={2001},
  volume={79 1},
  pages={63-70}
}
Intrastriatal injection of the reversible succinate dehydrogenase inhibitor malonate results in both chemically induced hypoxia and striatal lesions that are similar to those seen in Huntington's disease and cerebral ischaemia. The mechanisms leading to neuronal death involve secondary excitotoxicity, the release of dopamine from nigrostriatal fibres and the generation of reactive oxygen species (ROS) including nitric oxide (NO) and hydroxyl radicals. Here, we further investigated the… CONTINUE READING