Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex.

@article{Durstewitz2000DopaminemediatedSO,
  title={Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex.},
  author={Dr. D. Durstewitz and Jeremy K. Seamans and T J Sejnowski},
  journal={Journal of neurophysiology},
  year={2000},
  volume={83 3},
  pages={1733-50}
}
The prefrontal cortex (PFC) is critically involved in working memory, which underlies memory-guided, goal-directed behavior. During working-memory tasks, PFC neurons exhibit sustained elevated activity, which may reflect the active holding of goal-related information or the preparation of forthcoming actions. Dopamine via the D1 receptor strongly modulates both this sustained (delay-period) activity and behavioral performance in working-memory tasks. However, the function of dopamine during… CONTINUE READING
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