Dopamine-mediated actions of ephedrine in the rat substantia nigra

@article{Munhall2006DopaminemediatedAO,
  title={Dopamine-mediated actions of ephedrine in the rat substantia nigra},
  author={A. Munhall and S. Johnson},
  journal={Brain Research},
  year={2006},
  volume={1069},
  pages={96-103}
}
Although ephedrine is a centrally active stimulant, its effect on midbrain dopamine neurons is not known. To study the effect of ephedrine on dopamine-containing cells, current-clamp microelectrode recordings were made from substantia nigra pars compacta (SNC) neurons in horizontal brain slice preparations. Ephedrine (100-1000 microM) slowed spontaneous firing and produced a modest concentration-dependent hyperpolarization of membrane potential (EC50 279 microM), with a concomitant net decrease… Expand
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