Dopamine mechanisms play at best a small role in the nicotine discriminative stimulus.

@article{Corrigall1994DopamineMP,
  title={Dopamine mechanisms play at best a small role in the nicotine discriminative stimulus.},
  author={William A. Corrigall and Kathleen M. Coen},
  journal={Pharmacology, biochemistry, and behavior},
  year={1994},
  volume={48 3},
  pages={817-20}
}
The ability of D1 and D2 dopamine antagonists to reduce the subjective effects of nicotine was examined in rats trained to discriminate nicotine (0.3 mg/kg, base) from saline. Each of SCH 23390 (a D1 antagonist) and spiperone (a D2 antagonist) reduced responding on the drug-appropriate lever, and produced a reduction in overall response rates. The nicotine cue was also tested for generalization to the dopamine reuptake blocker GBR 12909. Doses of GBR 12909 that produced complete responding on… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
CocaineNo subtypeNicotine
Doses of GBR 12909 that produced complete responding on the drug - appropriate lever in cocaine - trained animals led to only minimal selection of the nicotine - appropriate lever in nicotine - trained animals ; as with the dopamine antagonists , response rates after GBR 12909 were markedly reduced in nicotine - trained , but not in cocaine - trained , rats .
Doses of GBR 12909 that produced complete responding on the drug - appropriate lever in cocaine - trained animals led to only minimal selection of the nicotine - appropriate lever in nicotine - trained animals ; as with the dopamine antagonists , response rates after GBR 12909 were markedly reduced in nicotine - trained , but not in cocaine - trained , rats .
Doses of GBR 12909 that produced complete responding on the drug - appropriate lever in cocaine - trained animals led to only minimal selection of the nicotine - appropriate lever in nicotine - trained animals ; as with the dopamine antagonists , response rates after GBR 12909 were markedly reduced in nicotine - trained , but not in cocaine - trained , rats .
Doses of GBR 12909 that produced complete responding on the drug - appropriate lever in cocaine - trained animals led to only minimal selection of the nicotine - appropriate lever in nicotine - trained animals ; as with the dopamine antagonists , response rates after GBR 12909 were markedly reduced in nicotine - trained , but not in cocaine - trained , rats .
Doses of GBR 12909 that produced complete responding on the drug - appropriate lever in cocaine - trained animals led to only minimal selection of the nicotine - appropriate lever in nicotine - trained animals ; as with the dopamine antagonists , response rates after GBR 12909 were markedly reduced in nicotine - trained , but not in cocaine - trained , rats .
Doses of GBR 12909 that produced complete responding on the drug - appropriate lever in cocaine - trained animals led to only minimal selection of the nicotine - appropriate lever in nicotine - trained animals ; as with the dopamine antagonists , response rates after GBR 12909 were markedly reduced in nicotine - trained , but not in cocaine - trained , rats .
NicotineNo subtypeCocaine
Doses of GBR 12909 that produced complete responding on the drug - appropriate lever in cocaine - trained animals led to only minimal selection of the nicotine - appropriate lever in nicotine - trained animals ; as with the dopamine antagonists , response rates after GBR 12909 were markedly reduced in nicotine - trained , but not in cocaine - trained , rats .
Doses of GBR 12909 that produced complete responding on the drug - appropriate lever in cocaine - trained animals led to only minimal selection of the nicotine - appropriate lever in nicotine - trained animals ; as with the dopamine antagonists , response rates after GBR 12909 were markedly reduced in nicotine - trained , but not in cocaine - trained , rats .
Doses of GBR 12909 that produced complete responding on the drug - appropriate lever in cocaine - trained animals led to only minimal selection of the nicotine - appropriate lever in nicotine - trained animals ; as with the dopamine antagonists , response rates after GBR 12909 were markedly reduced in nicotine - trained , but not in cocaine - trained , rats .
Doses of GBR 12909 that produced complete responding on the drug - appropriate lever in cocaine - trained animals led to only minimal selection of the nicotine - appropriate lever in nicotine - trained animals ; as with the dopamine antagonists , response rates after GBR 12909 were markedly reduced in nicotine - trained , but not in cocaine - trained , rats .
Doses of GBR 12909 that produced complete responding on the drug - appropriate lever in cocaine - trained animals led to only minimal selection of the nicotine - appropriate lever in nicotine - trained animals ; as with the dopamine antagonists , response rates after GBR 12909 were markedly reduced in nicotine - trained , but not in cocaine - trained , rats .
Doses of GBR 12909 that produced complete responding on the drug - appropriate lever in cocaine - trained animals led to only minimal selection of the nicotine - appropriate lever in nicotine - trained animals ; as with the dopamine antagonists , response rates after GBR 12909 were markedly reduced in nicotine - trained , but not in cocaine - trained , rats .
All Topics