Dopamine inhibits melatonin synthesis in photoreceptor cells through a D2-like receptor subtype in the rat retina: biochemical and histochemical evidence.

@article{NguyenLegros1996DopamineIM,
  title={Dopamine inhibits melatonin synthesis in photoreceptor cells through a D2-like receptor subtype in the rat retina: biochemical and histochemical evidence.},
  author={Jeanine Nguyen-Legros and Evelyne Chanut and Claudine Versaux-Bott{\'e}ri and Axelle Pascale Simon and J. H. Trouvin},
  journal={Journal of neurochemistry},
  year={1996},
  volume={67 6},
  pages={2514-20}
}
An intrinsic oscillator, using dopamine and melatonin as antagonist signals, controls rhythmic events in the retina of nonmammals. The purpose of the present work was to localize and characterize a dopamine receptor responsible for the nocturnal inhibition of melatonin synthesis in photoreceptor cells in a mammalian retina. An antibody against the D2 receptor stained photoreceptor cell inner segments of the rat retina. alpha-Methyl-p-tyrosine, a competitive inhibitor of tyrosine hydroxylase… CONTINUE READING