Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway.

@article{Luo1998DopamineIA,
  title={Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway.},
  author={Yongquan Luo and Hiroyuki Umegaki and Xiaoyang Wang and Ryo Abe and George S. Roth},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 6},
  pages={3756-64}
}
Dopamine (DA) is a neurotransmitter, but it also exerts a neurotoxic effect under certain pathological conditions, including age-related neurodegeneration such as Parkinson's disease. By using both the 293 cell line and primary neonatal rat postmitotic striatal neuron cultures, we show here that DA induces apoptosis in a time- and concentration-dependent manner. Concomitant with the apoptosis, DA activates the JNK pathway, including increases in JNK activity, phosphorylation of c-Jun, and… CONTINUE READING
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