Dopamine induces ERK activation in renal epithelial cells through H2O2 produced by monoamine oxidase.

@article{Vindis2001DopamineIE,
  title={Dopamine induces ERK activation in renal epithelial cells through H2O2 produced by monoamine oxidase.},
  author={C{\'e}cile Vindis and M H S{\'e}gu{\'e}las and Sophie Lanier and Angelo Parini and Claudie Cambon},
  journal={Kidney international},
  year={2001},
  volume={59 1},
  pages={76-86}
}
BACKGROUND The rat renal proximal tubule cells contain a large amount of monoamine oxidase, which catalyzes the oxidative deamination of catecholamines such as dopamine (DA). The aim of this study is to investigate the potential role of hydrogen peroxide (H2O2) produced by monoamine oxidase (MAO) isoform on regulation of cell signaling and function. METHODS Primary rat proximal tubular cells, which contain almost exclusively MAO-A, and human embryonic kidney 293 (HEK 293) cells stably… CONTINUE READING
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