Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility

@inproceedings{Chen2013DopamineII,
  title={Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility},
  author={Jane Y. Chen and Elizabeth A Wang and Carlos Cepeda and Michael S Levine},
  booktitle={Front. Neurosci.},
  year={2013}
}
Dopamine (DA) plays an essential role in the control of coordinated movements. Alterations in DA balance in the striatum lead to pathological conditions such as Parkinson's and Huntington's diseases (HD). HD is a progressive, invariably fatal neurodegenerative disease caused by a genetic mutation producing an expansion of glutamine repeats and is characterized by abnormal dance-like movements (chorea). The principal pathology is the loss of striatal and cortical projection neurons. Changes in… CONTINUE READING
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