Dopamine hyperpolarizes and reduces the light responses of rod ON-centre bipolar cells in the retina of the dogfish, Scyliorhinus canicula.

@article{Shiells1985DopamineHA,
  title={Dopamine hyperpolarizes and reduces the light responses of rod ON-centre bipolar cells in the retina of the dogfish, Scyliorhinus canicula.},
  author={Richard Shiells and G U Falk},
  journal={Neuroscience letters},
  year={1985},
  volume={55 3},
  pages={331-6}
}
Intracellular recordings were obtained from horizontal cells and bipolar cells of the dark-adapted, virtually all-rod retina of the dogfish. Eyecups were superfused with Ringer's solution containing micromolar concentrations of dopamine (DA). It was found that 10 microM DA hyperpolarized rod ON-centre bipolar cells and reduced their responses to light flashes. Detectable effects could be obtained with DA concentrations as low as 1 microM. A decrease in the light responses of bipolar cells due… CONTINUE READING