Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder

@article{Berk2007DopamineDS,
  title={Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder},
  author={Michael Berk and Seetal Dodd and M{\'a}rcia Kauer-Sant'Anna and Gin S. Malhi and Michel Bourin and Fl{\'a}vio Kapczinski and T Norman},
  journal={Acta Psychiatrica Scandinavica},
  year={2007},
  volume={116}
}
Objective:  Rational therapeutic development in bipolar is hampered by a lack of pathophysiological model. However, there is a wealth of converging data on the role of dopamine in bipolar disorder. This paper therefore examines the possibility of a dopamine hypothesis for bipolar disorder. 
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References

SHOWING 1-10 OF 82 REFERENCES
Dopamine and depression: A review of recent evidence. II. Theoretical approaches
  • P. Willner
  • Medicine, Psychology
  • Brain Research Reviews
  • 1983
TLDR
The meso-limbic and nigrostriatal DA system appears to be related primarily to responsiveness to the environment, and the role of dopamine (DA) in their related animal models is discussed. Expand
The role of dopamine in reward and pleasure behaviour – review of data from preclinical research
TLDR
The association between dopamine and unpleasant symptoms that are commonly found in neuropsychiatric disorders and may also be side‐effects of neuroleptic drugs are discussed. Expand
Central monoamine deficiency in depressions: causative of secondary phenomenon?
TLDR
There are indications for a functional deficiency of 5-HT and DA in certain kinds of depression and research with MA precursors drew the tentative conclusion that they are presumabely primary and interrelated with the depression in a causal and/or predisposing way. Expand
Dopamine and depression: A review of recent evidence. I. Empirical studies
  • P. Willner
  • Medicine, Psychology
  • Brain Research Reviews
  • 1983
TLDR
There is good evidence that the nigro-striatal DA system is underactive in retarded depressions, and some evidence that DA agonists are therapeutically effective in these cases, but it remains unclear whether changes in DA function are primary or secondary. Expand
A dopaminergic mechanism in mania.
TLDR
Observations suggest that dopaminergic mechanisms may be involved in the mediation of manic episodes in at least some patients. Expand
Dopamine dysregulation syndrome in Parkinson's disease
TLDR
Recognition of dopamine dysregulation syndrome and characterization of its phenomenology supports the notion that the medication used to treat Parkinson's disease can disrupt basal ganglia mediated motor and behavioural functioning. Expand
Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies.
TLDR
Hedonistic homeostatic dysregulation is a neuropsychological behavioural disorder associated with substance misuse and addiction that develops in male patients with early onset Parkinson's disease, and can occur with orally and subcutaneously administered DRT. Expand
Possible involvement of the dopamine D3 receptor locus in subtypes of bipolar affective disorder.
TLDR
Patients suffering from bipolar affective disorder who were compared with healthy volunteers exhibited a characteristic clinical pattern consisting of: manic monopolar form of bipolar disorder, low age of onset and initiation by an acute delusional episode, which could involve the dopamine D3 receptor locus as a minor effect gene in the manic depression condition. Expand
Perspectives for the development of animal models of bipolar disorder
TLDR
It is proposed that new genetics approaches involving potential animal models of BD are a promising new area for further development. Expand
[Dopamine dysregulation syndrome in Parkinson's disease].
TLDR
Sensitization of ventral striatal networks to antiparkinsonian therapy and appetitive behaviors may be analogous to the neuroplastic changes in the dorsal striatum thought to contribute to the motor complications of treatment such as dyskinesias. Expand
...
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5
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