Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research.

  title={Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research.},
  author={Mary V Solanto},
  journal={Behavioural brain research},
  volume={130 1-2},
There is strong evidence that the catecholamines dopamine and norepinephrine are both important in the pathophysiology of ADHD, as well as in the mechanism of therapeutic action of stimulant drugs. Due to the known effects of stimulants in blocking reuptake of catecholamines and (in the case of D-amphetamine) facilitating their release, it has traditionally been believed that the stimulants compensate for catecholamine deficiency in ADHD. More recently, however, alternate hypotheses of a… CONTINUE READING
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