Dopamine depletion, stimulation or blockade in the rat disrupts spatial navigation and locomotion dependent upon beacon or distal cues.

@article{Whishaw1985DopamineDS,
  title={Dopamine depletion, stimulation or blockade in the rat disrupts spatial navigation and locomotion dependent upon beacon or distal cues.},
  author={Ian Q. Whishaw and Stephen B. Dunnett},
  journal={Behavioural brain research},
  year={1985},
  volume={18 1},
  pages={11-29}
}
Rats depleted of dopamine by intraventricular or nigrostriatal bundle 6-hydroxydopamine injection were compared with normal rats on acquisition and retention of place and cue navigation in the Morris swimming pool test and on a battery of sensorimotor tests. Rats with extensive bilateral dopamine depletions were able to swim vigorously, but were unable to acquire either the place or cue task. Rats with unilateral lesions, although impaired in the rate of acquisition were eventually able to… CONTINUE READING

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