Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease

@article{Xu2002DopaminedependentNO,
  title={Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease},
  author={Jin Xu and Shyan-Yuan Kao and Frank J S Lee and Weihong Song and Lee-Way Jin and Bruce A. Yankner},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={600-606}
}
The mechanism by which dopaminergic neurons are selectively lost in Parkinson disease (PD) is unknown. Here we show that accumulation of α-synuclein in cultured human dopaminergic neurons results in apoptosis that requires endogenous dopamine production and is mediated by reactive oxygen species. In contrast, α-synuclein is not toxic in non-dopaminergic human cortical neurons, but rather exhibits neuroprotective activity. Dopamine-dependent neurotoxicity is mediated by 54–83-kD soluble protein… CONTINUE READING

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