Dopamine compartmentalization, selective dopaminergic vulnerabilities in Parkinson's disease and therapeutic opportunities

@inproceedings{Uhl2019DopamineCS,
  title={Dopamine compartmentalization, selective dopaminergic vulnerabilities in Parkinson's disease and therapeutic opportunities},
  author={George R. Uhl},
  booktitle={Annals of clinical and translational neurology},
  year={2019}
}
Progressive depletion of selected dopamine neurons is central to much Parkinson's disease (PD) disability. Although symptomatic treatments can ameliorate the disabilities that this neuronal depletion causes, no current strategy is documented to slow these losses. There is substantial evidence that dopamine in intracytoplasmic/extravesicular neuronal compartments can be toxic. Here, I review evidence that supports roles for dopamine compartmentalization, mediated largely by serial actions of… CONTINUE READING
BETA

References

Publications referenced by this paper.
SHOWING 1-10 OF 87 REFERENCES

Parkinson’s disease and parkinsonism: neuropathology

DW Dickson
  • Cold Spring Harb Perspect Med
  • 2012
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Functional properties of dopamine transporter oligomers after copper linking

J Zhen, Reith MEA
  • J Neurochem
  • 2018

New insights into the complex role of mitochondria in Parkinson’s disease

A Grunewald, KR Kumar, CM. Sue
  • Prog Neurobiol 2018
  • 2018
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…